Cisplatin-Based Chemotherapy of Testicular Cancer – Two Decades after a Major Breakthrough
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چکیده
منابع مشابه
Cisplatin-Based Chemotherapy of Testicular Cancer – two Decades After a Major Breakthrough
Two decades ago the introduction of cisplatin-based combination chemotherapy has dramatically improved the prognosis of patients with metastatic testicular cancer. At present 3 cycles of cisplatin, etoposide and bleomycin are considered as standard treatment for good-risk metastatic disease. Outside of clinical trials patients in the intermediate and poor prognosis categories should receive 4 c...
متن کاملEvaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer.
BACKGROUND Because of the increasing number of long-term survivors of metastatic testicular germ-cell cancer, a general concern has been secondary morbidities, especially cardiovascular risk factors. PATIENTS AND METHODS Thirty-two patients treated with cisplatin- and doxorubicin-containing chemotherapy > or = 13 years before the time of analyses were evaluated for neuro-, oto-, pulmonary-, v...
متن کاملPaternity and testicular function among testicular cancer survivors treated with two to four cycles of cisplatin-based chemotherapy.
BACKGROUND Preserved fertility is an important issue for testicular cancer (TC) survivors. OBJECTIVE Our aim was to examine any difference regarding paternity and testicular function following two, three, or four cycles of cisplatin-based chemotherapy for TC. DESIGN, SETTING, AND PARTICIPANTS A national multicentre follow-up survey assessing morbidity among survivors of unilateral TC diagno...
متن کاملThrombosis of internal carotid artery after cisplatin-based chemotherapy.
later, she found him lying by the bed unable to communicate and unable to move his right limbs. On admission 3 h later, he was somnolent, globally aphasic, and he had central paresis of the facial nerve and spastic hemiplegia with brisk reflexes and extensor plantar response on the right side. There were no clinical signs of deep venous thrombosis. A few months earlier, he had been diagnosed as...
متن کاملQuantitation of cis - Diamminedichloroplatinum 11 ( Cisplatin ) - DNA - lntrastrand Adducts in Testicular and Ovarian Cancer Patients Receiving Cisplatin Chemotherapy
The antitumor activity of cis-diamminedichloroplatinum II (cisplatin) is believed to be related to its covalent interaction with DNA where a major DNA binding product is an intrastrand N7bidentate adduct on adjacent deoxyguanosines. A novel immunoassay was used to quantitate this adduct in buffy coat DNA from testicular and ovarian cancer patients undergoing cisplatin therapy. 44 out of 120 sam...
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ژورنال
عنوان ژورنال: Oncology Research and Treatment
سال: 2000
ISSN: 2296-5270,2296-5262
DOI: 10.1159/000027081